Outcomes Predictor after Mastectomy with N1 Breast Cancer

This predictor is applicable to women with breast cancer who have upfront mastectomy, have a <=5cm tumor, and 1, 2, or 3 positive lymph nodes. Based on a combination of patient, disease, and treatment characteristics, the 5-year and 10-year predicted risks of local recurrence, distant recurrence, overall recurrence, and breast cancer mortality are calculated.

Note that 'optimal systemic therapy' includes endocrine therapy for patients with ER+ or PR+ disease, trastuzumab for patients with HER2+ disease, and chemotherapy for patients with ER- and PR- disease.

Age at diagnosis (years)

Pathologic tumor size (cm)

Number of lymph nodes sampled

Number of positive lymph nodes

Grade

Lymphovascular invasion

ER/PR status

HER2 status

Tumor location

Optimal systemic therapy

Reference

Sittenfeld, S., Zabor, E. C., Hamilton, S. N., Kuerer, H. M., El-Tamer, M., Naoum, G. E., Truong, P. T., Nichol, A., Smith, B. D., Woodward, W. A., Moo, T. A., Powell, S. N., Shah, C. S., Taghian, A. G., Abu-Gheida, I., & Tendulkar, R. D. (2022). A multi-institutional prediction model to estimate the risk of recurrence and mortality after mastectomy for T1-2N1 breast cancer. Cancer, 128(16), 3057–3066. https://doi.org/10.1002/cncr.34352

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